Mimics of GBS in The Netherlands
Date published: May 9, 2024
Accurate and rapid diagnosis of GBS is important for adequate monitoring and treatment of patients. Since there is no definitive test, the diagnosis is based on clinical symptoms and signs found during neurological examination. Early diagnosis is often difficult due to the large diversity in symptoms and course of the disease. Furthermore, other diseases can present with similar symptoms and can mimic GBS.
In this study, we use data from the Dutch GBS Mimics Study to determine the actual differential diagnosis of GBS in the Netherlands, evaluate the current clinical criteria for diagnosis of GBS and establish early discriminating factors between GBS and mimics of GBS. The results are important to improve the diagnostic process in daily practice.
A list of research articles
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The role of B lymphocytes in the progression of chronic immune-mediated neuropathies
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Study on CIDP
In addition, I am studying the role of B lymphocytes in the progression of chronic immune-mediated neuropathies, including Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Autoimmune Nodopathy (AN). Through this research, we strive to enhance diagnostics, clinical care, and treatment options for patients affected by these conditions.
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Detecting anti-paranodal antibodies
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Study on GBS
My research primarily focuses on investigating novel pathogenic antibodies in paranodal regions associated with immune-mediated neuropathies. The aim of my project is to improve diagnostic methods for detecting anti-paranodal antibodies and to determine the prevalence of these harmful autoantibodies in patients with Guillain-Barré Syndrome (GBS).
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Time to treatment study
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Study on GBS
In this project, we aim to describe the current practice of time to treatment. We also assess the association with functional outcome in patients with GBS who received first-line treatment with intravenous immunoglobulin or plasma exchange. This study is performed using data from the International GBS Outcome Study (IGOS).
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