Fc-gamma receptor (FcγR) polymorphisms and predisposition to develop GBS.
Date published: May 24, 2024
FcγRs are important for the effector functions of immunoglobulin G (IgG) and are therefore expected to play a role in the pathophysiology of GBS.
In this study, we identify the prevalence of genetic polymorphisms in the FCGR2/3 locus in patients with GBS using multiplex ligation-dependent probe amplification (MLPA).
We aim to investigate whether certain genetic changes within the FCGR2/3, or polymorphisms, influence susceptibility to GBS and the severity of the disease.
A list of research articles
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The role of B lymphocytes in the progression of chronic immune-mediated neuropathies
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Study on CIDP
In addition, I am studying the role of B lymphocytes in the progression of chronic immune-mediated neuropathies, including Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Autoimmune Nodopathy (AN). Through this research, we strive to enhance diagnostics, clinical care, and treatment options for patients affected by these conditions.
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Detecting anti-paranodal antibodies
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Study on GBS
My research primarily focuses on investigating novel pathogenic antibodies in paranodal regions associated with immune-mediated neuropathies. The aim of my project is to improve diagnostic methods for detecting anti-paranodal antibodies and to determine the prevalence of these harmful autoantibodies in patients with Guillain-Barré Syndrome (GBS).
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Time to treatment study
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Study on GBS
In this project, we aim to describe the current practice of time to treatment. We also assess the association with functional outcome in patients with GBS who received first-line treatment with intravenous immunoglobulin or plasma exchange. This study is performed using data from the International GBS Outcome Study (IGOS).
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