Study on GBS
List of articles
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Detecting anti-paranodal antibodies
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Study on GBS
My research primarily focuses on investigating novel pathogenic antibodies in paranodal regions associated with immune-mediated neuropathies. The aim of my project is to improve diagnostic methods for detecting anti-paranodal antibodies and to determine the prevalence of these harmful autoantibodies in patients with Guillain-Barré Syndrome (GBS).
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Time to treatment study
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Study on GBS
In this project, we aim to describe the current practice of time to treatment. We also assess the association with functional outcome in patients with GBS who received first-line treatment with intravenous immunoglobulin or plasma exchange. This study is performed using data from the International GBS Outcome Study (IGOS).
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Fc-gamma receptor (FcγR) polymorphisms and predisposition to develop GBS.
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Study on GBS
FcγRs are important for the effector functions of immunoglobulin G (IgG) and are therefore expected to play a role in the pathophysiology of GBS. In this study, we identify the prevalence of genetic polymorphisms in the FCGR2/3 locus in patients with GBS using multiplex ligation-dependent probe amplification (MLPA). We aim to investigate whether certain genetic […]
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Should we individualize IVIG treatment in patients with GBS?
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Study on GBS
A significant number of patients with GBS does not respond to the arbitrarily defined standard dosing regimen of intravenous immunoglobulin (IVIg). In this study, we aim to investigate the relationship between the pharmacokinetics (PK) – what the body does to the drug – and the clinical outcome (pharmacodynamics). The goal is to identify patients who […]
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Mimics of GBS in The Netherlands
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Study on GBS
Accurate and rapid diagnosis of GBS is important for adequate monitoring and treatment of patients. Since there is no definitive test, the diagnosis is based on clinical symptoms and signs found during neurological examination. Early diagnosis is often difficult due to the large diversity in symptoms and course of the disease. Furthermore, other diseases can […]
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Evaluation of new treatments for GBS using real-world data
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Study on GBS
A substantial proportion of patients with GBS do not respond sufficiently to the current proven effective treatment with intravenous immunoglobulins (IVIg) or plasma exchange. The rarity of the disease challenges the conduct of clinical trials, with no new effective treatments found in the past 30 years. Improved designs for conducting treatment studies and novel treatment […]
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Genome Wide association study in patients with GBS
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Study on GBS
In this study, we aim to investigate whether genetics (single nucleotide polymorphisms) could play a role in a patient’s susceptibility to develop GBS. This study is performed using clinical data and blood samples from patients included in the International GBS Outcome Study (IGOS) and several previous Dutch treatment trials.
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Nfl prognostic model
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Study on GBS
In this study, we aim to explore whether addition of the biomarker neurofilament light chain, a blood marker for nerve damage, to the existing mEGRIS and mEGOS prediction tools could further improve the performance of these tools. This study is performed using clinical data and blood samples from patients included in the second intravenous immunoglobulin […]
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Anti-ganglioside antibodies in patients with GBS
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Study on GBS
In this study, we aim to determine the presence of anti-ganglioside antibodies in patients with GBS and explore whether these are related to symptoms and prognosis. This study is performed using clinical data and blood samples from patients included in the International GBS Outcome Study (IGOS).
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International GBS Outcome Study (IGOS)
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Study on GBS
International GBS Outcome Study (IGOS)Worldwide research into the cause, diagnosis, treatment and prognosis of GBS. Background: Guillain-Barré Syndrome (GBS) is an inflammation of the nerves that can lead to rapidly progressive and very severe paralysis of the arms, legs and respiratory muscles. GBS is usually caused by the immune response to an infection. GBS can […]
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GBS Mimics Study
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Study on GBS
BackgroundGuillain-Barré Syndrome (GBS) is a disorder of the peripheral nerves. These nerves provide the connection between the brain and spinal cord and the muscles and skin. If this connection is damaged by GBS, this leads to serious loss of strength, loss of sensation and pain. GBS is caused by inflammation of these nerves and treatment […]
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